Saturday, January 7, 2012

Howdoes the influenza evade the immune response, in particular T-cell mediated and antibody-mediated responses?

I took virology a few years ago, but I seem to remember the influenza virus having highly variable surface proteins, which the human immune system uses to target it for antibody-directed carnage. For instance, lets say you had the flu one year, and your body ended up making antibodies for it, so that you cannot get it again. Then, the next year, a new strain, with different surface proteins, from Asia (why are the new strains always from Asia, by the way?) comes along, and since it is shaped differently on the surface, the antibodies from last year's visitor cannot attach, and therefore cannot target it for antibody-directed carnage!!!!!! I'd check my facts on this, because I don't remember exactly what the antibodies like sticking to on the influenza virus surface.

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